<i>Candida</i> spp. with Acquired Echinocandin Resistance, France, 2004–20101

2012126 citationsJournal Articlediamond Open Access

Authors

Éric Dannaoui · Centre National de la Recherche Scientifique

Marie Desnos‐Ollivier · Génomes, biologie cellulaire et thérapeutiques

Dea Garcia‐Hermoso · Génomes, biologie cellulaire et thérapeutiques

Frédéric Grenouillet · Laboratoire Chrono-Environnement

Sophie Cassaing · Centre Hospitalier Universitaire de Toulouse

Marie-Thérèse Baixench · Hôpital Cochin

Stéphane Bretagne

Abstract

We report 20 episodes of infection caused by acquired echinocandin-resistant Candida spp. harboring diverse and new Fksp mutations. For 12 patients, initial isolates (low MIC, wild-type Fksp sequence) and subsequent isolates (after caspofungin treatment, high MIC, mutated Fksp) were genetically related.

Topics & Keywords

Antifungal resistance and susceptibility Fungal Infections and Studies Pneumocystis jirovecii pneumonia detection and treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Emerging infectious diseases

Volume 18, Issue 1, pp. 86-90

DOI: 10.3201/eid1801.110556

Field-Weighted Citation Impact: 9.62