Changes in expression and activity of CD38 in astroglial cells after impairment of the neuron-glia relationship in the brain induced by perinatal hypoxia-ischemia

We studied changes in the expression and activity of a bifunctional enzyme, CD38, in neurons and glia induced by perinatal hypoxia-ischemia in rats. These changes influenced reactive gliosis and functional coupling between ADP-ribosyl cyclase and connexin 43 in the development of neuron-glia interactions.