Pharmacokinetics and Efficacy of PEGylated Liposomal Doxorubicin in an Intracranial Model of Breast Cancer

201388 citationsJournal Articlegold Open Access

Authors

Carey K. Anders · UNC Lineberger Comprehensive Cancer Center

Bárbara Adamo · University of North Carolina at Chapel Hill

Olga Karginova · University of North Carolina at Chapel Hill

Allison M. Deal · UNC Lineberger Comprehensive Cancer Center

Sumit Rawal · UNC Lineberger Comprehensive Cancer Center

David B. Darr · University of North Carolina at Chapel Hill

Allison N. Schorzman

Abstract

PLD provides both PK and efficacy advantage over NonL-doxo in the treatment of an in vivo model of BCBM. The results provide preclinical rationale to translate findings into early phase trials of PLD, with or without ABT-888, for patients with BCBM.

Topics & Keywords

Brain Metastases and Treatment Lung Cancer Research Studies Nanoplatforms for cancer theranostics

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 8, Issue 5, pp. e61359-e61359

DOI: 10.1371/journal.pone.0061359

Field-Weighted Citation Impact: 6.40