Failure of immunologic criteria to appropriately identify antiretroviral treatment failure in Uganda

2009183 citationsJournal Articlegreen Open Access

Authors

Steven J. Reynolds · Reynolds American (United States)

Gertrude Nakigozi · Rakai Health Sciences Program

Kevin Newell · Science Applications International Corporation (United States)

Anthony Ndyanabo · Rakai Health Sciences Program

Ronald Galiwongo · Rakai Health Sciences Program

Boaz Iga · Rakai Health Sciences Program

Thomas C. Quinn

Abstract

Immunologic failure criteria performed poorly in our setting and would have resulted in a substantial proportion of participants with suppressed HIV-1 viral load being switched unnecessarily. These criteria also lacked sensitivity to identify participants failing virologically. Periodic viral load measurements may be a better marker for treatment failure in our setting.

Topics & Keywords

HIV/AIDS Research and Interventions HIV Research and Treatment HIV/AIDS drug development and treatment

Publication Details

Published in: AIDS

Volume 23, Issue 6, pp. 697-700

DOI: 10.1097/qad.0b013e3283262a78

Field-Weighted Citation Impact: 12.69

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Failure of immunologic criteria to appropriately identify antiretroviral treatment failure in Uganda

Authors

Abstract

Topics & Keywords

Publication Details