Local Delivery of Human Tissue Kallikrein Gene Accelerates Spontaneous Angiogenesis in Mouse Model of Hindlimb Ischemia

2001189 citationsJournal Articlegreen Open Access

Authors

Costanza Emanueli · Istituto Nazionale Biostrutture e Biosistemi

Alessandra Minasi · University of Sassari

Antonella Zacheo · University of Sassari

Julie Chao · Istituto Nazionale Biostrutture e Biosistemi

Lee Chao · Istituto Nazionale Biostrutture e Biosistemi

Maria Bonaria Salis · University of Sassari

Stefania Straino

Abstract

HK gene delivery enhances the native angiogenic response to ischemia. Angiogenesis gene therapy with HK might be applicable to peripheral occlusive vascular disease.

Topics & Keywords

Angiogenesis and VEGF in Cancer Coagulation, Bradykinin, Polyphosphates, and Angioedema Neurobiology and Insect Physiology Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 103, Issue 1, pp. 125-132

DOI: 10.1161/01.cir.103.1.125

Field-Weighted Citation Impact: 6.48