Long‐term effects of metformin on endothelial function in type 2 diabetes: a randomized controlled trial

2013126 citationsJournal Articlegreen Open Access

Authors

J. de Jager · Academic Medical Center

Adriaan Kooy · Ziekenhuis Bethesda

Casper G. Schalkwijk · Maastricht University

J. van der Kolk · Ziekenhuis Bethesda

Philippe Lehert · UCLouvain

D. Bets · Merck & Co., Inc., Rahway, NJ, USA (United States)

M. G. Wulffelé ·

Abstract

Metformin is associated with improvement in some (vWF and sVCAM-1) but not all markers of endothelial function, which may explain why it is associated with a decreased risk of CV disease in type 2 diabetes.

Topics & Keywords

Adipokines, Inflammation, and Metabolic Diseases Diabetes Treatment and Management Pharmacology and Obesity Treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Internal Medicine

Volume 275, Issue 1, pp. 59-70

DOI: 10.1111/joim.12128

Field-Weighted Citation Impact: 4.88