NOA-04 Randomized Phase III Trial of Sequential Radiochemotherapy of Anaplastic Glioma With Procarbazine, Lomustine, and Vincristine or Temozolomide

2009804 citationsJournal Article

Authors

Wolfgang Wick · Heidelberg University

Christian Hartmann · Heidelberg University

Corinna Engel · Heidelberg University

Mandy Stoffels · Heidelberg University

Jörg Felsberg · Heidelberg University

Florian Stockhammer · Heidelberg University

Michael Sabel ·

Abstract

Initial radiotherapy or chemotherapy achieved comparable results in patients with anaplastic gliomas. IDH1 mutations are a novel positive prognostic factor in anaplastic gliomas, with a favorable impact stronger than that of 1p/19q codeletion or MGMT promoter methylation.

Topics & Keywords

Glioma Diagnosis and Treatment Brain Metastases and Treatment Cancer, Hypoxia, and Metabolism

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Clinical Oncology

Volume 27, Issue 35, pp. 5874-5880

DOI: 10.1200/jco.2009.23.6497

Field-Weighted Citation Impact: 28.83