Large‐scale analysis of association between <i>GDF5</i> and <i>FRZB</i> variants and osteoarthritis of the hip, knee, and hand

Evidence of an association between the GDF5 rs143383 polymorphism and OA is substantially strong, but the genetic effects are consistent across different populations only for knee OA. Findings of this collaborative analysis do not support the notion that FRZB rs7775 or rs288326 has any sizable genetic effect on OA phenotypes.