Relation Between Folate Status, a Common Mutation in Methylenetetrahydrofolate Reductase, and Plasma Homocysteine Concentrations

19961,400 citationsJournal Article

Authors

Paul F. Jacques · Framingham Heart Study

Andrew G. Bostom · Framingham Heart Study

Roger R. Williams · University of Minnesota

R. Curtis Ellison · Framingham Heart Study

John H. Eckfeldt · University of Utah

Irwin H. Rosenberg · University of Minnesota

Jacob Selhub ·

Abstract

Individuals with thermolabile MTHFR may have a higher folate requirement for regulation of plasma homocysteine concentrations; folate supplementation may be necessary to prevent fasting hyperhomocysteinemia in such persons.

Topics & Keywords

Folate and B Vitamins Research Esophageal and GI Pathology Child Nutrition and Feeding Issues

Publication Details

Published in: Circulation

Volume 93, Issue 1, pp. 7-9

DOI: 10.1161/01.cir.93.1.7

Field-Weighted Citation Impact: 71.34

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Relation Between Folate Status, a Common Mutation in Methylenetetrahydrofolate Reductase, and Plasma Homocysteine Concentrations

Authors

Abstract

Topics & Keywords

Publication Details