Influence of Prenatal Arsenic Exposure and Newborn Sex on Global Methylation of Cord Blood DNA

2012157 citationsJournal Articlegold Open Access

Authors

J. Richard Pilsner · University of Massachusetts Amherst

Megan N. Hall · Columbia University

Xinhua Liu · Columbia University

Vesna Ilievski · Columbia University

Vesna Slavkovich · Columbia University

David T. Levy · Columbia University

Pam Factor‐Litvak ·

Abstract

These results suggest that prenatal As exposure is associated with global DNA methylation in cord blood DNA, possibly in a sex-specific manner. Arsenic-induced epigenetic modifications in utero may potentially influence disease outcomes later in life. Additional studies are needed to confirm these findings and to examine the persistence of DNA methylation marks over time.

Topics & Keywords

Birth, Development, and Health Selenium in Biological Systems Heavy Metal Exposure and Toxicity

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 7, Issue 5, pp. e37147-e37147

DOI: 10.1371/journal.pone.0037147

Field-Weighted Citation Impact: 26.65