Sequence Variations in <i>PCSK9,</i> Low LDL, and Protection against Coronary Heart Disease

20063,155 citationsJournal Articlebronze Open Access

Authors

Jonathan C. Cohen · Cardiovascular Research Center

Eric Boerwinkle · The University of Texas Health Science Center at Houston

Helen H. Hobbs · Southwestern Medical Center

Abstract

These data indicate that moderate lifelong reduction in the plasma level of LDL cholesterol is associated with a substantial reduction in the incidence of coronary events, even in populations with a high prevalence of non-lipid-related cardiovascular risk factors.

Topics & Keywords

Lipoproteins and Cardiovascular Health Diabetes, Cardiovascular Risks, and Lipoproteins Genetic Associations and Epidemiology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 354, Issue 12, pp. 1264-1272

DOI: 10.1056/nejmoa054013

Field-Weighted Citation Impact: 93.39