Resistance to Levofloxacin and Failure of Treatment of Pneumococcal Pneumonia

2002537 citationsJournal Articlebronze Open Access

Authors

Ross Davidson

Rodrigo B. Cavalcanti · University of Toronto

James Brunton · University Health Network

Darrin J. Bast · University of Toronto

Joyce C. S. de Azavedo · University of Toronto

Pamela Kibsey

Christine Fleming · Ontario Medical Association

Donald E. Low

Abstract

This report describes four patients with pneumococcal pneumonia in whom empirical treatment with levofloxacin failed. In these patients, the isolates of Streptococcus pneumoniae were resistant to levofloxacin, and in two of them the resistance appeared to have been acquired during the current course of treatment with fluoroquinolones.

Topics & Keywords

Pneumonia and Respiratory Infections Antibiotics Pharmacokinetics and Efficacy Antimicrobial Resistance in Staphylococcus

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 346, Issue 10, pp. 747-750

DOI: 10.1056/nejmoa012122

Field-Weighted Citation Impact: 66.07