Bilirubin-Induced Neurologic Damage — Mechanisms and Management Approaches

2013371 citationsReview

Authors

Jon F. Watchko · University of Pittsburgh

Claudio Tiribelli · Fondazione Italiana Fegato

Abstract

The complex cascade of molecular and cellular events leading to bilirubin-induced neurotoxicity remains incompletely delineated. This review discusses bilirubin-induced brain damage and recent insights into its pathogenesis and prevention.

Topics & Keywords

Neonatal Health and Biochemistry Heme Oxygenase-1 and Carbon Monoxide Methemoglobinemia and Tumor Lysis Syndrome

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 369, Issue 21, pp. 2021-2030

DOI: 10.1056/nejmra1308124

Field-Weighted Citation Impact: 34.87