α-Hydroxybutyrate Is an Early Biomarker of Insulin Resistance and Glucose Intolerance in a Nondiabetic Population

2010700 citationsJournal Articlegold Open Access

Authors

Walter Gall · Metabolon (United States)

Kirk Beebe · Metabolon (United States)

Kay A. Lawton · Metabolon (United States)

Klaus‐Peter Adam · Metabolon (United States)

Matthew Mitchell · Metabolon (United States)

Pamela J. Nakhle · Metabolon (United States)

John Ryals ·

Abstract

alpha-hydroxybutyrate is an early marker for both insulin resistance and impaired glucose regulation. The underlying biochemical mechanisms may involve increased lipid oxidation and oxidative stress.

Topics & Keywords

Diet and metabolism studies Metabolomics and Mass Spectrometry Studies Metabolism, Diabetes, and Cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 5, Issue 5, pp. e10883-e10883

DOI: 10.1371/journal.pone.0010883

Field-Weighted Citation Impact: 13.31