MRI correlates of neurofibrillary tangle pathology at autopsy

2008362 citationsJournal Articlebronze Open Access

Authors

Jennifer L. Whitwell · Neurology, Inc

Keith A. Josephs · Neurology, Inc

Melissa E. Murray · Neurology, Inc

Kejal Kantarci · Neurology, Inc

Scott A. Przybelski · Neurology, Inc

Stephen D. Weigand · Neurology, Inc

Prashanthi Vemuri ·

Abstract

Patterns of gray matter loss are associated with neurofibrillary tangle (NFT) pathology, specifically with NFT burden at Braak stages III and IV and with Braak stage itself at higher stages. This validates three-dimensional patterns of atrophy on MRI as an approximate in vivo surrogate indicator of the full brain topographic representation of the neurodegenerative aspect of Alzheimer disease pathology.

Topics & Keywords

Dementia and Cognitive Impairment Research Advanced Neuroimaging Techniques and Applications Alzheimer's disease research and treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Neurology

Volume 71, Issue 10, pp. 743-749

DOI: 10.1212/01.wnl.0000324924.91351.7d

Field-Weighted Citation Impact: 9.87