Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease

2010522 citationsJournal Article

Authors

Takahiko Tokuda · Kyoto Prefectural University of Medicine

M.M. Qureshi · Kyoto Prefectural University of Medicine

Mustafa T. Ardah · Kyoto Prefectural University of Medicine

Sheeja Varghese · Kyoto Prefectural University of Medicine

Safa Shehab · Kyoto Prefectural University of Medicine

Takashi Kasai · Kyoto Prefectural University of Medicine

Noriko Ishigami

Abstract

Our results demonstrate that levels of α-synuclein oligomers in CSF and the oligomers/total-α-synuclein ratio can be useful biomarkers for diagnosis and early detection of PD.

Topics & Keywords

Parkinson's Disease Mechanisms and Treatments Neurological disorders and treatments Nuclear Receptors and Signaling

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Neurology

Volume 75, Issue 20, pp. 1766-1770

DOI: 10.1212/wnl.0b013e3181fd613b

Field-Weighted Citation Impact: 20.89