Arsenic-related DNA copy-number alterations in lung squamous cell carcinomas

201047 citationsJournal Articlehybrid Open Access

Authors

Victor D. Martínez · University of Chile

Timon P.H. Buys · Occupational Cancer Research Centre

Marta Adonis · University of Chile

Hugo Benítez · Hospital Regional de Antofagasta

Iván Gallegos · Hospital Clínico de la Universidad de Chile

Stephen Lam · Occupational Cancer Research Centre

Wan L. Lam

Abstract

Our results provide a comprehensive approach to molecular characteristics of the arsenic-exposed lung cancer genome and the non-smoking lung SqCC genome. The distinct and recurrent arsenic-related alterations suggest that this group of tumours may be considered as a separate disease subclass.

Topics & Keywords

Genomic variations and chromosomal abnormalities Cancer Genomics and Diagnostics DNA Repair Mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: British Journal of Cancer

Volume 103, Issue 8, pp. 1277-1283

DOI: 10.1038/sj.bjc.6605879

Field-Weighted Citation Impact: 2.46

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