Anthracycline Dose Intensification in Acute Myeloid Leukemia

2009902 citationsJournal Articlebronze Open Access

Authors

Hugo F. Fernández · Moffitt Cancer Center

Zhuoxin Sun · Dana-Farber Cancer Institute

Xiaopan Yao · Dana-Farber Cancer Institute

Mark R. Litzow · Mayo Clinic in Arizona

Selina M. Luger · University of Pennsylvania

Elisabeth Paietta · Montefiore Medical Center

Janis Racevskis ·

Abstract

In young adults with AML, intensifying induction therapy with a high daily dose of daunorubicin improved the rate of complete remission and the duration of overall survival, as compared with the standard dose. (ClinicalTrials.gov number, NCT00049517.)

Topics & Keywords

Acute Myeloid Leukemia Research Neutropenia and Cancer Infections Retinoids in leukemia and cellular processes

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 361, Issue 13, pp. 1249-1259

DOI: 10.1056/nejmoa0904544

Field-Weighted Citation Impact: 29.85