Colorectal Cancer Stem Cells Are Enriched in Xenogeneic Tumors Following Chemotherapy

2008582 citationsJournal Articlegold Open Access

Authors

Scott J. Dylla · OncoMed (United States)

Lucia Beviglia · OncoMed (United States)

In‐Kyung Park · OncoMed (United States)

Cécile Chartier · OncoMed (United States)

Janak Raval · OncoMed (United States)

Lucy Ngan · OncoMed (United States)

Kellie Pickell ·

Abstract

CoCSC are enriched in colon tumors following chemotherapy and remain capable of rapidly regenerating tumors from which they originated. By focusing on the biology of CoCSC, major resistance mechanisms to specific chemotherapeutic agents can be attributed to specific genes, thereby suggesting avenues for improving cancer therapy.

Topics & Keywords

Cancer Cells and Metastasis Cancer, Hypoxia, and Metabolism FOXO transcription factor regulation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 3, Issue 6, pp. e2428-e2428

DOI: 10.1371/journal.pone.0002428

Field-Weighted Citation Impact: 21.00