Analysis of cell‐free <scp>DNA</scp> in maternal blood in screening for fetal aneuploidies: updated meta‐analysis

2015804 citationsReview

Authors

M. M. Gil · Harris Birthright Research Centre for Fetal Medicine

Ranjit Akolekar · Medway Maritime Hospital

K. H. Nicolaides · Harris Birthright Research Centre for Fetal Medicine

Abstract

Screening by analysis of cfDNA in maternal blood in singleton pregnancies could detect > 99% of fetuses with trisomy 21, 98% of trisomy 18 and 99% of trisomy 13 at a combined FPR of 0.13%. The number of reported cases of SCA is too small for accurate assessment of performance of screening. In twin pregnancies, performance of screening for trisomy 21 is encouraging but the number of cases reported is small. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.

Topics & Keywords

Prenatal Screening and Diagnostics Parvovirus B19 Infection Studies Tumors and Oncological Cases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Ultrasound in Obstetrics and Gynecology

Volume 45, Issue 3, pp. 249-266

DOI: 10.1002/uog.14791

Field-Weighted Citation Impact: 217.27