A Genetic Risk Factor for Periodic Limb Movements in Sleep

2007621 citationsJournal Articlebronze Open Access

Authors

Hreinn Stefánsson · deCODE Genetics (Iceland)

David B. Rye · Emory University

Andrew A. Hicks · deCODE Genetics (Iceland)

Hjörvar Pétursson · deCODE Genetics (Iceland)

Andrés Ingason · deCODE Genetics (Iceland)

Thorgeir E. Thorgeirsson · deCODE Genetics (Iceland)

Stefan Palsson

Abstract

We have discovered a variant associated with susceptibility to periodic limb movements in sleep. The inverse correlation of the variant with iron stores is consistent with the suspected involvement of iron depletion in the pathogenesis of the disease.

Topics & Keywords

Restless Legs Syndrome Research Parkinson's Disease Mechanisms and Treatments Sleep and Wakefulness Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 357, Issue 7, pp. 639-647

DOI: 10.1056/nejmoa072743

Field-Weighted Citation Impact: 35.03