Age, nutritional status and INH acetylator status affect pharmacokinetics of anti-tuberculosis drugs in children

201390 citationsJournal Article

Authors

Geetha Ramachandran · Indian Council of Medical Research

A K Hemanth Kumar · National Institute of Research in Tuberculosis

Perumal Kannabiran Bhavani · Indian Council of Medical Research

N. Poorana Gangadevi · Indian Council of Medical Research

L Sekar · National Institute of Research in Tuberculosis

D. Vijayasekaran · Institute of Child Health

V.V. Banu Rekha

Abstract

Children aged <3 years had significantly lower RMP, INH and PZA concentrations than older children, and 90% of all children had sub-therapeutic RMP Cmax (<8 μg/ml). Age, nutritional status and INH acetylator status influenced drug levels. Peak RMP and INH concentrations were important determinants of treatment outcome. Recommendations for anti-tuberculosis treatment in children should take these factors into consideration.

Topics & Keywords

Tuberculosis Research and Epidemiology Antibiotics Pharmacokinetics and Efficacy Pharmaceutical studies and practices

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: The International Journal of Tuberculosis and Lung Disease

Volume 17, Issue 6, pp. 800-806

DOI: 10.5588/ijtld.12.0628

Field-Weighted Citation Impact: 4.59