The synthesis of XTT: A new tetrazolium reagent that is bioreducible to a water‐soluble formazan

1988150 citationsJournal Article

Authors

Kenneth D. Paull · National Cancer Institute

Robert H. Shoemaker · National Cancer Institute

Michael R. Boyd · National Cancer Institute

Jack L. Parsons · Starks Associates

Prabhakar Risbood · Starks Associates

William A. Barbera · Starks Associates

Mahenda N. Sharma ·

Abstract

Abstract A new tetrazolium salt, XTT, has been synthesized. XTT is reduced by a considerable variety of cell lines to a water‐soluble formazan. XTT appears to merit further investigation as a reagent for broader application to cell culture assay systems.

Topics & Keywords

Nanofabrication and Lithography Techniques RNA Interference and Gene Delivery bioluminescence and chemiluminescence research

UN Sustainable Development Goals

Clean water and sanitation

Publication Details

Published in: Journal of Heterocyclic Chemistry

Volume 25, Issue 3, pp. 911-914

DOI: 10.1002/jhet.5570250340

Field-Weighted Citation Impact: 5.40