Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone

19733,534 citationsJournal Article

Authors

Paul Brazeau · Salk Institute for Biological Studies

Wylie Vale · Salk Institute for Biological Studies

Roger Burgus · Salk Institute for Biological Studies

Nicholas Ling · Salk Institute for Biological Studies

Madalyn Butcher · Salk Institute for Biological Studies

Jean Rivier · Salk Institute for Biological Studies

Roger Guillemin

Abstract

A peptide has been isolated from ovine hypothalamus which, at 1 x 10(-9)M, inhibits secretion in vitro of immunoreactive rat or human growth hormones and is similarly active in vivo in rats. Its structure is H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH The synthetic replicate is biologically active.

Topics & Keywords

Growth Hormone and Insulin-like Growth Factors

Publication Details

Published in: Science

Volume 179, Issue 4068, pp. 77-79

DOI: 10.1126/science.179.4068.77

Field-Weighted Citation Impact: 78.66

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Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone

Authors

Abstract

Topics & Keywords

Publication Details