Neutrophils from patients with <i>TNFRSF1A</i> mutations display resistance to tumor necrosis factor–induced apoptosis: Pathogenetic and clinical implications

Resistance to TNF-mediated apoptosis is a feature in TRAPS patients who have mutations of cysteine residues or interstitial deletion, and may play a pathogenic role. The R92Q mutation does not appear to be significantly associated with TRAPS.