Length Dependence of Tension Generation in Rat Skinned Cardiac Muscle

2001184 citationsJournal Articlebronze Open Access

Authors

Norio Fukuda · Jikei University School of Medicine

Daisuke Sasaki · Jikei University School of Medicine

Shin’ichi Ishiwata · Jikei University School of Medicine

Satoshi Kurihara · Jikei University School of Medicine

Abstract

The length-dependent activation in cardiac muscle, an underlying mechanism of the Frank-Starling law of the heart, is at the myofilament level, predominantly modulated by titin and interfilament lattice spacing changes.

Topics & Keywords

Cardiomyopathy and Myosin Studies Muscle Physiology and Disorders Cardiovascular Effects of Exercise

Publication Details

Published in: Circulation

Volume 104, Issue 14, pp. 1639-1645

DOI: 10.1161/hc3901.095898

Field-Weighted Citation Impact: 7.12

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Length Dependence of Tension Generation in Rat Skinned Cardiac Muscle

Authors

Abstract

Topics & Keywords

Publication Details