NGF-mediated transcriptional targets of p53 in PC12 neuronal differentiation

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Authors

Christopher Brynczka · National Institute of Environmental Health Sciences

Paul Labhart · Pathway Genomics (United States)

B. Alex Merrick · National Institute of Environmental Health Sciences

Abstract

Within the PC12 neuronal context, putative p53-occupied genomic loci spanned the entire Rattus norvegicus genome upon NGF treatment. We conclude that receptor-mediated p53 transcriptional activity is involved in PC12 differentiation and may suggest a contributory role for p53 in neuronal development.

Topics & Keywords

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: BMC Genomics

Volume 8, Issue 1, pp. 139-139

DOI: 10.1186/1471-2164-8-139

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