High-throughput single nucleotide polymorphism genotyping using nanofluidic Dynamic Arrays

2009179 citationsJournal Articlegold Open Access

Authors

Jun Wang · Fluidigm (United States)

Min Lin

Andrew Crenshaw · National Cancer Institute

Amy Hutchinson · Science Applications International Corporation (United States)

Belynda Hicks · Division of Cancer Epidemiology and Genetics

Meredith Yeager · National Cancer Institute

Sonja I. Berndt · National Cancer Institute

Abstract

Our results demonstrate that the Dynamic Array is an excellent genotyping system for medium-throughput multiplexing (30-300 SNPs), which is simple to use and combines rapid throughput with excellent call rates, high concordance and low cost. The exceptional call rates and call accuracy obtained may be of particular interest to those working on validation and replication of genome- wide- association (GWA) studies.

Topics & Keywords

Gene expression and cancer classification Microfluidic and Capillary Electrophoresis Applications Single-cell and spatial transcriptomics

Publication Details

Published in: BMC Genomics

Volume 10, Issue 1, pp. 561-561

DOI: 10.1186/1471-2164-10-561

Field-Weighted Citation Impact: 2.82

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High-throughput single nucleotide polymorphism genotyping using nanofluidic Dynamic Arrays

Authors

Abstract

Topics & Keywords

Publication Details