Brain grey matter volume alterations in late-life depression

2014139 citationsReviewbronze Open Access

Authors

Mingying Du · Sichuan University

Jia Liu · West China Hospital of Sichuan University

Ziqi Chen · West China Hospital of Sichuan University

Xiaoqi Huang · West China Hospital of Sichuan University

Jing Li · Sichuan University

Weihong Kuang · West China Hospital of Sichuan University

Yanchun Yang

Abstract

The present meta-analysis is, to our knowledge, the first to overcome previous inconsistencies in the VBM studies of LLD and provide robust evidence for grey matter alterations within fronto-striatal-limbic networks, thereby implicating them in the pathophysiology of LLD. The mean age and the percentage of female patients with LLD did not appear to have a measurable impact on grey matter changes, although we cannot rule out the contributory effects of medication.

Topics & Keywords

Functional Brain Connectivity Studies Memory and Neural Mechanisms Neurotransmitter Receptor Influence on Behavior

Publication Details

Published in: Journal of Psychiatry and Neuroscience

Volume 39, Issue 6, pp. 397-406

DOI: 10.1503/jpn.130275

Field-Weighted Citation Impact: 4.69

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Brain grey matter volume alterations in late-life depression

Authors

Abstract

Topics & Keywords

Publication Details