Effects of Recombinant Apolipoprotein A-I <sub>Milano</sub> on Aortic Atherosclerosis in Apolipoprotein E–Deficient Mice

1998236 citationsJournal Article

Authors

Prediman K. Shah · Cedars-Sinai Medical Center

Jan Nilsson · Cedars-Sinai Medical Center

Sanjay Kaul · Cedars-Sinai Medical Center

Michael C. Fishbein · Cedars-Sinai Medical Center

Hans Ageland · Cedars-Sinai Medical Center

Anders Hamsten · Cedars-Sinai Medical Center

Jan Johansson

Abstract

Recombinant A-I(Milano)/PC prevented progression of aortic atherosclerosis and reduced lipid and macrophage content of plaques in apo E-deficient mice despite severe hypercholesterolemia. Thus, A-I(Milano)/PC may have a role in inhibiting progression and promoting stabilization of atherosclerosis.

Topics & Keywords

Lipoproteins and Cardiovascular Health Diabetes, Cardiovascular Risks, and Lipoproteins Atherosclerosis and Cardiovascular Diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 97, Issue 8, pp. 780-785

DOI: 10.1161/01.cir.97.8.780

Field-Weighted Citation Impact: 11.66