Milrinone Relaxes Pulmonary Veins in Guinea Pigs and Humans

201432 citationsJournal Articlegold Open Access

Authors

Annette D. Rieg · FH Aachen

Said Suleiman

Alberto Pérez-Bouza · FH Aachen

Till Braunschweig · FH Aachen

Jan Spillner · FH Aachen

Thomas Schröder · Luisenhospital Aachen

Eva Verjans · FH Aachen

Gereon Schälte

Abstract

Milrinone relaxes PVs from GPs and humans. In GPs, milrinone-induced relaxation is based on K ATP-, BK Ca (2+)- and Kv-channel-activation and on cAMP/PKA/PKG. The relaxant properties of milrinone on PVs lead to reduced postcapillary resistance and hydrostatic pressures. Hence they alleviate pulmonary edema and suggest beneficial effects of milrinone in PH due to left heart disease.

Topics & Keywords

Pulmonary Hypertension Research and Treatments Phosphodiesterase function and regulation Nitric Oxide and Endothelin Effects

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 9, Issue 1, pp. e87685-e87685

DOI: 10.1371/journal.pone.0087685

Field-Weighted Citation Impact: 2.17