Propofol Dosing Regimens for ICU Sedation Based upon an Integrated Pharmacokinetic– Pharmacodynamic Model

2001165 citationsJournal Articlebronze Open Access

Authors

Juliana Barr · VA Palo Alto Health Care System

Talmage D. Egan · University of Utah

Nancy F. Sandoval · Highland Hospital

Katayoun Zomorodi · Stanford University

Carol Cohane · Stanford University

Pedro L. Gambús · Sociedade Brasileira de Anestesiologia

Steven L. Shafer ·

Abstract

Emergence time from sedation with propofol in ICU patients varies with the depth of sedation, the duration of sedation, and the patient's body habitus. Maintaining a light level of sedation ensures a rapid emergence from sedation with long-term propofol administration.

Topics & Keywords

Anesthesia and Sedative Agents Intensive Care Unit Cognitive Disorders Anesthesia and Neurotoxicity Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Anesthesiology

Volume 95, Issue 2, pp. 324-333

DOI: 10.1097/00000542-200108000-00011

Field-Weighted Citation Impact: 5.39