Polymorphism of the prion protein is associated with cognitive impairment in the elderly

199869 citationsJournal Article

Authors

Claudine Berr · Inserm

F. Richard · Inserm

Carole Dufouil · Inserm

Carole Amant · Inserm

A Alpérovitch · Inserm

Philippe Amouyel · Inserm

Abstract

This observation suggests that variability of the PRNP locus may be associated with cognitive performance in the elderly. This result, if confirmed, offers potential clues for the role of PRNP in the human brain.

Topics & Keywords

Prion Diseases and Protein Misfolding Amino Acid Enzymes and Metabolism Alzheimer's disease research and treatments

UN Sustainable Development Goals

Quality Education

Publication Details

Published in: Neurology

Volume 51, Issue 3, pp. 734-737

DOI: 10.1212/wnl.51.3.734

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