<i>Klebsiella pneumoniae</i> OmpA Confers Resistance to Antimicrobial Peptides

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Authors

Enrique Llobet · Fundació Balear d'Innovació i Tecnologia

Catalina March · Centro de Investigación Biomédica en Red de Enfermedades Respiratorias

Paloma Giménez · Centro de Investigación Biomédica en Red de Enfermedades Respiratorias

José A. Bengoechea · Centro de Investigación Biomédica en Red de Enfermedades Respiratorias

Abstract

A Klebsiella pneumoniae ompA mutant was more susceptible to antimicrobial peptides (APs) than the wild type. Susceptibility did not result from surface changes other than the absence of OmpA. Our data suggest that OmpA is implicated in the activation of yet-unknown systems dedicated to ameliorating AP cytotoxicity.

Topics & Keywords

Antimicrobial Peptides and Activities Antibiotic Resistance in Bacteria Bacterial biofilms and quorum sensing

Publication Details

Published in: Antimicrobial Agents and Chemotherapy

Volume 53, Issue 1, pp. 298-302

DOI: 10.1128/aac.00657-08

Field-Weighted Citation Impact: 1.13

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<i>Klebsiella pneumoniae</i> OmpA Confers Resistance to Antimicrobial Peptides

Authors

Abstract

Topics & Keywords

Publication Details