Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: A randomized, double‐blind, placebo‐controlled study using acetaminophen as a side comparator

The findings of this study indicate that glucosamine sulfate at the oral once-daily dosage of 1,500 mg is more effective than placebo in treating knee OA symptoms. Although acetaminophen also had a higher responder rate compared with placebo, it failed to show significant effects on the algofunctional indexes.