Interlaboratory Agreement of Insulin-like Growth Factor 1 Concentrations Measured by Mass Spectrometry

2013104 citationsJournal Articlebronze Open Access

Authors

Holly D. Cox

Filipe Lopes · King's College London

Getachew Assefa Woldemariam · University of California, Los Angeles

Jessica O. Becker · University of Washington

Mark C. Parkin · King's College London

Andreas Thomas · German Sport University Cologne

Anthony W. Butch · University of California, Los Angeles

Abstract

LC-MS measurements of IGF-1 by intact and trypsin-digestion methods are not statistically different and each is similar to immunoassay. The two LC-MS approaches may be used interchangeably or together to eliminate concerns regarding an immunoassay IGF-1 measurement. Because intact and digested IGF-1 measurements generally agreed within 20% of each other, we propose this as a criterion of assay acceptability.

Topics & Keywords

Metabolism, Diabetes, and Cancer Growth Hormone and Insulin-like Growth Factors Cancer, Hypoxia, and Metabolism

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Chemistry

Volume 60, Issue 3, pp. 541-548

DOI: 10.1373/clinchem.2013.208538

Field-Weighted Citation Impact: 4.47