Interleukin-6 as a Therapeutic Target in Human Ovarian Cancer

2011383 citationsJournal Articlegreen Open Access

Authors

Jermaine Coward · Cancer Research UK Manchester Institute

Hagen Kulbe · Cancer Research UK Manchester Institute

Probir Chakravarty · Royal London Hospital

David P. Leader · Cancer Research UK Manchester Institute

Vessela Vassileva · Cancer Research UK Manchester Institute

David A. Leinster · University of Manchester

R. Thompson

Abstract

IL-6 stimulates inflammatory cytokine production, tumor angiogenesis, and the tumor macrophage infiltrate in ovarian cancer and these actions can be inhibited by a neutralizing anti-IL-6 antibody in preclinical and clinical studies.

Topics & Keywords

Ovarian cancer diagnosis and treatment Cytokine Signaling Pathways and Interactions Chemokine receptors and signaling

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 17, Issue 18, pp. 6083-6096

DOI: 10.1158/1078-0432.ccr-11-0945

Field-Weighted Citation Impact: 37.96