Activation of Blood Coagulation After Cardiac Arrest Is Not Balanced Adequately by Activation of Endogenous Fibrinolysis

1995255 citationsJournal Article

Authors

Bernd W. Böttiger · Heidelberg University

J. Motsch · Heidelberg University

H. Böhrer · Heidelberg University

Thomas Böker · Heidelberg University

M. Aulmann · Heidelberg University

Peter P. Nawroth · Heidelberg University

Eike Martin ·

Abstract

Our data clearly demonstrate that there is a marked activation of blood coagulation and fibrin formation after prolonged cardiac arrest and CPR in humans that is not balanced adequately by concomitant activation of endogenous fibrinolysis. These changes may contribute to reperfusion disorders, such as the cerebral "no-reflow" phenomenon, by inducing fibrin deposition and formation of microthrombi.

Topics & Keywords

Cardiac Arrest and Resuscitation Injury Epidemiology and Prevention Trauma and Emergency Care Studies

Publication Details

Published in: Circulation

Volume 92, Issue 9, pp. 2572-2578

DOI: 10.1161/01.cir.92.9.2572

Field-Weighted Citation Impact: 6.78

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Activation of Blood Coagulation After Cardiac Arrest Is Not Balanced Adequately by Activation of Endogenous Fibrinolysis

Authors

Abstract

Topics & Keywords

Publication Details