The Role of the Plasma from Platelet Concentrates in Transfusion Reactions

1994490 citationsJournal Articlebronze Open Access

Authors

Nancy M. Heddle · McMaster University

Luba Klama

Joel Singer · University of British Columbia

Abstract

Bioreactive substances in the plasma supernatant of the platelet product cause most febrile reactions associated with platelet transfusions. Removing the plasma supernatant before transfusion can minimize or prevent these reactions.

Topics & Keywords

Blood transfusion and management Blood groups and transfusion Platelet Disorders and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 331, Issue 10, pp. 625-628

DOI: 10.1056/nejm199409083311001

Field-Weighted Citation Impact: 13.22