Determinants of iron accumulation in deep grey matter of multiple sclerosis patients

201454 citationsJournal Article

Authors

Stefan Ropele · Medical University of Graz

Iris D. Kilsdonk · Amsterdam UMC Location VUmc

Mike P. Wattjes · Amsterdam UMC Location VUmc

Christian Langkammer · Medical University of Graz

Wolter L. de Graaf · Amsterdam UMC Location VUmc

Jette Lautrup Frederiksen · Copenhagen University Hospital

Henrik Larsson

Abstract

Iron accumulation in deep GM of MS patients is most strongly and independently associated with duration and severity of the disease. Additional associations between cortical GM atrophy and deep GM iron accumulation appear to exist in a region specific manner.

Topics & Keywords

Multiple Sclerosis Research Studies RNA regulation and disease Ultrasound and Hyperthermia Applications

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Multiple Sclerosis Journal

Volume 20, Issue 13, pp. 1692-1698

DOI: 10.1177/1352458514531085

Field-Weighted Citation Impact: 5.48