Inhibition of Neointimal Proliferation With Low-Dose Irradiation From a β-Particle–Emitting Stent

1996155 citationsJournal Article

Authors

John R. Laird · Armed Forces Institute of Pathology

Andrew J. Carter · Walter Reed Army Institute of Research

William M. Kufs · Walter Reed Army Institute of Research

Timothy G. Hoopes · Walter Reed Army Institute of Research

Andrew Farb · Boston Scientific (Netherlands)

Sepideh H. Nott · Boston Scientific (Netherlands)

Robert E. Fischell

Abstract

A local, continuous source of low-dose endovascular irradiation via a beta-particle-emitting stent inhibits neointimal formation in porcine arteries. This low dose of local irradiation did not prevent endothelialization of the stents. This novel technique offers promise for the prevention of restenosis and warrants further investigation.

Topics & Keywords

Coronary Interventions and Diagnostics Cardiac Imaging and Diagnostics Aortic aneurysm repair treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 93, Issue 3, pp. 529-536

DOI: 10.1161/01.cir.93.3.529

Field-Weighted Citation Impact: 33.33