Analysis of the kinetics of osteoclastogenesis in arthritic rats

200560 citationsJournal Article

Authors

Georg Schett · Amgen (United States)

Marina Stolina · Medical University of Vienna

Brad Bolon · NewPath Research

Scot Middleton · Medical University of Vienna

Matthew Adlam · Medical University of Vienna

Heather Brown · Medical University of Vienna

Li Zhu ·

Abstract

Functional osteoclasts are generated at the earliest stage of arthritis, and new precursors are continuously formed in the synovial membrane to replenish the osteoclast pool. These data indicate that anti-resorptive therapies may provide the most effective bone protection, when treatment is started soon after the onset of arthritis.

Topics & Keywords

Bone Metabolism and Diseases Bone health and treatments Orthopaedic implants and arthroplasty

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Arthritis & Rheumatism

Volume 52, Issue 10, pp. 3192-3201

DOI: 10.1002/art.21343

Field-Weighted Citation Impact: 1.35