Bone-Marrow Suppression Associated with Cimetidine

Brief Reports1 October 1979Bone-Marrow Suppression Associated with CimetidineHENRY K. CHANG, M.D., STEPHEN L. MORRISON, M.D.HENRY K. CHANG, M.D.Search for more papers by this author, STEPHEN L. MORRISON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-4-580 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMetiamide, an H2-receptor antagonist, was withdrawn from human use because of its side effect of granulocytopenia, including one case of fatal agranulocytosis (1). This side effect was thought to be due to its thiourea moiety causing bone-marrow suppression. Cimetidine, a newer H2-receptor antagonist, differs from metiamide in that the thiourea moiety is replaced by a cyanoguanidine side chain. Since cimetidine's introduction in July 1974, five cases of agranulocytosis and two cases of pancytopenia, all reversible, have been implicated with its use (2). We present here a case of fatal bone-marrow suppression associated with cimetidine use.A 66-year-old white man was...References1. FELDMANISENBERG EJ. Effects of methiamide on gastric acid hypersecretion, steatorrhea and bone-marrow function in a patient with systemic mastocytosis. N Engl J Med. 1976;295:1178-9. CrossrefMedlineGoogle Scholar2. DE GALOCSYVAN YPERSELE DE STRIHOU CC. Pancytopenia with cimetidine. Ann Intern Med. 1979;90:274. Letter. LinkGoogle Scholar3. YUNISBLOOMBERG AG. Chloramphenicol toxicity: clinical features and pathogenesis. Prog Hematol. 1964;4:138-59. MedlineGoogle Scholar4. FRESTON J. Cimetidine and granulocytopenia. Ann Intern Med. 1979;90:264-5. Editorial. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Mercy San Juan Hospital Carmichael, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAntihistaminesAntihistaminesIs cimetidine associated with neutropenia?Safety of acid-suppressing drugsCimetidine induced pancytopeniaAlteration by burn injury of the pharmacokinetics and pharmacodynamics of cimetidine in childrenHaematological Adverse Effects of Histamine H2-Receptor AntagonistsSafety perspectives on parenteral H2-receptor antagonistsClinically Important Adverse Effects and Drug Interactions with H 2 -Receptor Antagonists: An UpdateContinuous intragastric pH measurement in the critically ill and treatment with parenteral ranitidineHistopathology of the bone marrow in toxic myelopathyCimetidine suppression of CFU-C in malesEffect of cimetidine on granulocyte-macrophage colony formation by normal and chronic renal failure bone marrow cellsHistamine H2-receptor Antagonists in the Short- and Long-term Treatment of Duodenal UlcerThe bioavailability and pharmacokinetics of cimetidine and its metabolites in juvenile cystic fibrosis patients: Age related differences as compared to adultsSide Effects of Histamine2-Receptor AntagonistsReview of Cimetidine Drug InteractionsCimetidine-Associated ThrombocytopeniaDrugs Five Years Later Cimetidine II. Adverse Reactions and Patterns of UseJAMES W. FRESTON, M.D., Ph.D.EFFECTS OF CIMETIDINE ON HAEMATOPOIESIS in vitroFATAL AGRANULOCYTOSIS ATTRIBUTABLE TO CIMETIDINEHow Physicians Use CimetidineA consideration of the adverse effects of cimetidineAntihistaminesCimetidine and hematologic suppressionNew medical and surgical treatments for peptic ulcer diseaseCimetidine and Granulopoiesis: Bone Marrow Culture Studies in Normal Man and Patients with Cimetidine-associated NeutropeniaCimetidine Used IndiscriminatelySevere Granulocytopenia with Cimetidine and PhenytoinELIZABETH SAZIE, M.D., JEFFRY P. JAFFE, M.D.Cimetidine-lnduced GranulocytopeniaHARRY W. CARLOSS, M.D., MEHDI TAVASSOLI, M.D., ROBERT MCMILLAN, M.D.Malignant scleroderma associated with autoimmune neutropenia.Peroperative venography to ensure accurate sapheno-popliteal vein ligation. 1 October 1979Volume 91, Issue 4Page: 580-580 Issue Published: 1 October 1979 Copyright© 1979 American College of PhysiciansPDF DownloadLoading ...