Development of Autoantibodies before the Clinical Onset of Systemic Lupus Erythematosus

20032,547 citationsJournal Articlebronze Open Access

Authors

Melissa R. Arbuckle · Oklahoma Medical Research Foundation

Micah T. McClain · University of Oklahoma Health Sciences Center

Mark V. Rubertone

R. Hal Scofield · Oklahoma Medical Research Foundation

G. Dennis · National Institute of Arthritis and Musculoskeletal and Skin Diseases

Judith A. James · University of Oklahoma Health Sciences Center

John B. Harley · University of Oklahoma Health Sciences Center

Abstract

Autoantibodies are typically present many years before the diagnosis of SLE. Furthermore, the appearance of autoantibodies in patients with SLE tends to follow a predictable course, with a progressive accumulation of specific autoantibodies before the onset of SLE, while patients are still asymptomatic.

Topics & Keywords

Systemic Lupus Erythematosus Research Monoclonal and Polyclonal Antibodies Research T-cell and B-cell Immunology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 349, Issue 16, pp. 1526-1533

DOI: 10.1056/nejmoa021933

Field-Weighted Citation Impact: 55.69