Sustained activation of vascular cells and leukocytes in the rabbit aorta after balloon injury.

1993266 citationsJournal Articlebronze Open Access

Authors

H. Tanaka · Brigham and Women's Hospital

Galina K. Sukhova · Brigham and Women's Hospital

Scott J. Swanson · Brigham and Women's Hospital

Steven K. Clinton · Brigham and Women's Hospital

Peter Ganz · Brigham and Women's Hospital

Myron I. Cybulsky · Brigham and Women's Hospital

Peter Libby

Abstract

Local inflammatory activation of endothelial cells, SMCs, and leukocytes occurs in a predictable sequence and persists up to 30 days after balloon injury to the rabbit aorta. Our findings suggest that ongoing local signals persisting after the original balloon injury may contribute to later phases of intimal thickening.

Topics & Keywords

Atherosclerosis and Cardiovascular Diseases Neutrophil, Myeloperoxidase and Oxidative Mechanisms Lipoproteins and Cardiovascular Health

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 88, Issue 4, pp. 1788-1803

DOI: 10.1161/01.cir.88.4.1788

Field-Weighted Citation Impact: 3.49