Abnormal expression of hepatoma specific ?-glutamyl transferase and alteration of ?-glutamyl transferase gene methylation status in patients with hepatocellular carcinoma

2000144 citationsJournal Articlebronze Open Access

Authors

Dengfu Yao

Daorong Jiang

Zhongwei Huang

Jianxin Lu

Qiyuan Tao

Zhijian Yu · Nanyang Medical College

Xianyong Meng

Abstract

The abnormal alteration of serum HS-GGT level is a sensitive tumor marker for HCC diagnosis or differentiation, and the overexpression of GGT in HCC may be related to the hypomethylational status of CCGG sites of GGT genes.

Topics & Keywords

Liver Disease Diagnosis and Treatment Folate and B Vitamins Research Epigenetics and DNA Methylation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cancer

Volume 88, Issue 4, pp. 761-769

DOI: 10.1002/(sici)1097-0142(20000215)88:4<761::aid-cncr5>3.0.co;2-5

Field-Weighted Citation Impact: 1.77