Nanoparticle-based delivery of siDCAMKL-1 increases microRNA-144 and inhibits colorectal cancer tumor growth via a Notch-1 dependent mechanism

2011154 citationsJournal Articlegold Open Access

Authors

Sripathi M. Sureban · University of Oklahoma Health Sciences Center

Randal May · University of Oklahoma Health Sciences Center

Fadee Mondalek

Dongfeng Qu · University of Oklahoma Health Sciences Center

Sivapriya Ponnurangam

Panayotis Pantazis

Shrikant Anant · University Hospital and Clinics

Rama P. Ramanujam · Applied Decision Science (United States)

Abstract

These findings demonstrate that nanoparticle-based delivery of siRNAs directed at critical targets such as DCAMKL-1 may provide a novel approach to treat cancer through the regulation of endogenous miRNAs.

Topics & Keywords

MicroRNA in disease regulation RNA Interference and Gene Delivery RNA Research and Splicing

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Nanobiotechnology

Volume 9, Issue 1, pp. 40-40

DOI: 10.1186/1477-3155-9-40

Field-Weighted Citation Impact: 4.50