Innovative Collagen Nano‐Hydroxyapatite Scaffolds Offer a Highly Efficient Non‐Viral Gene Delivery Platform for Stem Cell‐Mediated Bone Formation

2012206 citationsJournal Article

Authors

Caroline M. Curtin · Royal College of Surgeons in Ireland

Gráinne M. Cunniffe · Trinity College Dublin

Frank Lyons · Royal College of Surgeons in Ireland

Kazuhisa Bessho · Kyoto University

Glenn R. Dickson

Garry P. Duffy · Royal College of Surgeons in Ireland

Fergal J. O’Brien · Trinity College Dublin

Abstract

The ability of nano-hydroxyapatite (nHA) particles developed in-house to act as non-viral delivery vectors is assessed. These nHA particles are combined with collagen to yield bioactive, biodegradable collagen nano-hydroxyapatite (coll-nHA) scaffolds. Their ability to act as gene-activated matrices for BMP2 delivery is demonstrated with successful transfection of mesenchymal stem cells (MSCs) resulting in high calcium production.

Topics & Keywords

Bone Tissue Engineering Materials Tissue Engineering and Regenerative Medicine 3D Printing in Biomedical Research

Publication Details

Published in: Advanced Materials

Volume 24, Issue 6, pp. 749-754

DOI: 10.1002/adma.201103828

Field-Weighted Citation Impact: 11.30

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Innovative Collagen Nano‐Hydroxyapatite Scaffolds Offer a Highly Efficient Non‐Viral Gene Delivery Platform for Stem Cell‐Mediated Bone Formation

Authors

Abstract

Topics & Keywords

Publication Details