Molecular Regulation of Hepatic Fibrosis, an Integrated Cellular Response to Tissue Injury

Encapsulation of injury with fibrosis is a highly evolved response of adult tissues. In liver, the components of the process have been greatly clarified, leading to a coherent view of how wound healing occurs in response to injury. Hepatic fibrogenesis provides an important biological and clinical context for emerging concepts in molecular biochemistry that is relevant to many other tissues.