Effects of thyroid status on expression of voltage-gated potassium channels in rat left ventricle

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Authors

Atsushi Nishiyama · Japanese Circulation Society

Abstract

Thyroid hormone differentially regulates the expression of Kv1.4, Kv1.5, Kv2.1 and Kv4.2 mRNA levels in the rat left ventricle. This effect is not mediated through beta-adrenergic signaling pathway. On the other hand, the reduction in Kv1.2 mRNA level was associated with cardiac hypertrophy induced by T4 or Iso.

Topics & Keywords

Ion channel regulation and function Cardiac electrophysiology and arrhythmias Receptor Mechanisms and Signaling

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cardiovascular Research

Volume 40, Issue 2, pp. 343-351

DOI: 10.1016/s0008-6363(98)00135-7

Field-Weighted Citation Impact: 1.65